EXO5

Across TCGA patient cohorts, EXO5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,158 significant associations in total. THCA shows the largest number of these associations.

The most reproducible EXO5-associated GO terms across cancer lineages are Interstrand cross-link repair, Regulation of cilium assembly, and DNA-templated DNA replication maintenance of fidelity. Each is linked with EXO5 in more than 30 cancer types. Because this analysis shows association rather than direction, both EXO5-to-partner and partner-to-EXO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interstrand cross-link repair grouped by EXO5-low versus EXO5-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXO5→partner) and Y-score (partner→EXO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Interstrand cross-link repair →	+0.063	+0.577	<.001	.001	2	31
ESCA	Regulation of cilium assembly →	+0.060	+0.810	<.001	<.001	3	29
THYM	DNA-templated DNA replication maintenance of fidelity →	+0.046	+0.566	<.001	<.001	3	29
THYM	Negative regulation of gene expression, epigenetic →	+0.063	+0.686	<.001	<.001	3	29
THYM	Regulation of RNA export from nucleus →	+0.077	+0.480	<.001	<.001	3	29
ESCA	Regulation of DNA replication →	+0.067	+0.646	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,158 associations by consensus.

Interstrand cross-link repair by EXO5 expression — SCLC

Explore this box plot interactively →