EXO5

Across TCGA patient cohorts, EXO5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXO5-associated genes across cancer lineages are Akt, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with EXO5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXO5-to-partner and partner-to-EXO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by EXO5-low versus EXO5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXO5→partner) and Y-score (partner→EXO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.349	-3.700	.001	.001	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.722	+3.179	.002	.010	3	2
UCEC	INPP4B →	-0.349	-3.321	.020	.009	3	2
UCEC	TFRC →	+0.682	+2.584	.005	.011	3	2
UCEC	CDK1 →	+0.154	+2.820	.028	.035	3	2
UCEC	c-Met_pY1235 →	+0.096	+2.331	.005	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Akt by EXO5 expression — UCEC

Explore this box plot interactively →