EXO1

Across TCGA patient cohorts, EXO1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXO1-associated genes across cancer lineages are eIF4E, FoxM1, and Notch1. Each is linked with EXO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXO1-to-partner and partner-to-EXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EXO1-low versus EXO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXO1→partner) and Y-score (partner→EXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.173	+3.183	.020	.009	3	3
UCEC	FoxM1 →	+0.212	+1.362	.020	.037	3	2
UCEC	Notch1 →	+0.166	+2.713	<.001	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.439	-2.459	.005	.018	3	2
UCEC	ATM →	-0.350	-1.362	.029	.037	3	2
COAD	C-Raf →	+0.195	+2.815	.015	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by EXO1 expression — UCEC

Explore this box plot interactively →