EXO1

Across TCGA cell cohorts, EXO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,315 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EXO1-associated GO terms across cancer lineages are Mitotic DNA replication, DNA integrity checkpoint signaling, and Cell cycle DNA replication. Each is linked with EXO1 in more than 19 cancer types. Because this analysis shows association rather than direction, both EXO1-to-partner and partner-to-EXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by EXO1-low versus EXO1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXO1→partner) and Y-score (partner→EXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Mitotic DNA replication →	+0.200	+1.339	<.001	<.001	3	20
PANCREAS	DNA integrity checkpoint signaling →	+0.088	+1.378	<.001	<.001	3	20
BONE	Cell cycle DNA replication →	+0.180	+1.724	.005	.001	3	20
URINARY_TRACT	DNA replication →	+0.108	+1.036	<.001	<.001	3	20
BLOOD_Myeloma	DNA-templated DNA replication →	+0.124	+1.924	<.001	<.001	3	20
BONE	Nuclear DNA replication →	+0.183	+1.691	.005	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,315 associations by consensus.

Mitotic DNA replication by EXO1 expression — PANCREAS

Explore this box plot interactively →