Across TCGA patient cohorts, EXD3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXD3-associated genes across cancer lineages are Caspase-7-cleavedD198, Akt, and PREX1. Each is linked with EXD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXD3-to-partner and partner-to-EXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXD3→partner) and Y-score (partner→EXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.752	+1.882	.023	.031	2	3
COAD	Akt →	-0.459	-2.576	.017	.011	3	1
COAD	PREX1 →	+0.196	+3.182	.024	.009	3	1
COAD	S6_pS235_S236 →	+0.409	+1.882	.038	.031	3	1
COAD	S6_pS240_S244 →	+0.400	+1.900	.015	.030	3	1
COAD	beta-Catenin →	-0.704	-3.000	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

EXD3 survival (RNA) · tumor vs normal (RNA) · all EXD3 data types