EXD2

Across TCGA patient cohorts, EXD2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXD2-associated genes across cancer lineages are Heregulin, INPP4B, and JNK_pT183_Y185. Each is linked with EXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXD2-to-partner and partner-to-EXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by EXD2-low versus EXD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXD2→partner) and Y-score (partner→EXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.147	-3.156	.004	.018	3	1
UCEC	INPP4B →	-0.438	-2.807	.001	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.146	-1.794	.035	.027	3	1
UCEC	MEK1 →	+0.417	+2.321	.005	.006	3	1
UCEC	Myosin-IIa_pS1943 →	+0.188	+1.820	.027	.016	3	1
UCEC	Myosin-IIa →	+0.164	+1.707	.036	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Heregulin by EXD2 expression — UCEC

Explore this box plot interactively →