EXD1

Across TCGA patient cohorts, EXD1 mutation is significantly associated with the RNA expression of many other genes, with 2,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXD1-associated genes across cancer lineages are DAGLB, RN7SL237P, and RN7SKP221. Each is linked with EXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXD1-to-partner and partner-to-EXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAGLB grouped by EXD1-low versus EXD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXD1→partner) and Y-score (partner→EXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAGLB →	+0.237	+2.439	.008	.001	3	2
CESC	RN7SL237P →	+0.153	+5.418	<.001	.005	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	ARRDC1-AS1 →	+0.348	+2.136	.001	.009	3	2
UCEC	IGHD4-17 →	+0.536	+2.036	<.001	.009	3	2
LUSC	SNRPGP7 →	+0.452	+5.474	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

DAGLB by EXD1 expression — UCEC

Explore this box plot interactively →