EXD1

Across TCGA cell cohorts, EXD1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EXD1-associated genes across cancer lineages are HTR1A, VNN3, and CEACAM3. Each is linked with EXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXD1-to-partner and partner-to-EXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1A grouped by EXD1-low versus EXD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXD1→partner) and Y-score (partner→EXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR1A →	+0.006	+5.000	<.001	<.001	3	1
SKIN	VNN3 →	+0.188	+3.920	<.001	.005	3	1
CNS	CEACAM3 →	+0.058	+4.321	<.001	.009	3	1
BLOOD_Leukemia	F9 →	+0.011	+3.969	<.001	.009	3	1
BLOOD_Leukemia	DEFB125 →	+0.036	+3.475	<.001	.006	3	1
BLOOD_Leukemia	SLC9A4 →	+0.016	+4.147	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HTR1A by EXD1 expression — SKIN

Explore this box plot interactively →