EWSR1

Across TCGA pan-cancer cohorts, EWSR1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EWSR1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EWSR1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EWSR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, COAD, and LSCC are the cancer types where EWSR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.927	0.787	.020	16	view →
COAD	DFS	Tertile	All	1.000	0.880	.041	12	view →
LSCC	DFS	Median	III,IV	0.850	1.000	.009	7	view →
HNSC	DFS	Quartile	III,IV	0.487	0.773	.015	6	view →
GBM	OS	Median	All	0.472	0.293	.025	4	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
LUAD	DFS	Quartile	All	0.594	1.000	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EWSR1–UCEC (DFS)

Open the UCEC breakdown →