EWSR1

Across TCGA patient cohorts, EWSR1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EWSR1-associated genes across cancer lineages are CDK1, EGFR_pY1068, and mTOR_pS2448. Each is linked with EWSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EWSR1-to-partner and partner-to-EWSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by EWSR1-low versus EWSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EWSR1→partner) and Y-score (partner→EWSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.130	+2.820	.036	.035	3	3
UCEC	EGFR_pY1068 →	-0.207	-3.459	.045	.005	3	2
UCEC	mTOR_pS2448 →	-0.148	-2.302	.016	.034	3	2
UCEC	Notch1 →	+0.173	+2.335	.002	.018	3	2
UCEC	PCNA →	+0.310	+3.584	<.001	.002	3	2
COAD	MIG-6 →	+0.107	+3.229	.028	.009	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CDK1 by EWSR1 expression — UCEC

Explore this box plot interactively →