EWSR1

Across TCGA cell cohorts, EWSR1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EWSR1-associated genes across cancer lineages are OR2T2, SSMEM1, and REG1B. Each is linked with EWSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EWSR1-to-partner and partner-to-EWSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T2 grouped by EWSR1-low versus EWSR1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EWSR1→partner) and Y-score (partner→EWSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR2T2 →	+0.153	+5.285	<.001	.003	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1
LARGE_INTESTINE	REG1B →	+2.745	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.022	+4.169	.001	.007	3	1
BLOOD_Leukemia	CBY1 →	+0.526	+3.351	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR2T2 by EWSR1 expression — STOMACH

Explore this box plot interactively →