EVX2

Across TCGA patient cohorts, EVX2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVX2-associated genes across cancer lineages are EGFR_pY1068, GSK-3_pS9, and NF-kB-p65_pS536. Each is linked with EVX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EVX2-to-partner and partner-to-EVX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EVX2-low versus EVX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVX2→partner) and Y-score (partner→EVX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.257	-3.169	.034	.019	3	1
UCEC	GSK-3_pS9 →	-0.546	-2.999	.005	.035	3	1
UCEC	NF-kB-p65_pS536 →	-0.616	-3.160	.004	.019	3	1
UCEC	Annexin-1 →	+0.720	+3.019	.004	.019	3	1
UCEC	Src_pY416 →	-0.241	-2.446	.038	.020	3	1
UCEC	Src_pY527 →	-0.616	-2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by EVX2 expression — UCEC

Explore this box plot interactively →