Across TCGA patient cohorts, EVPLL mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVPLL-associated genes across cancer lineages are GSK-3_pS9, GSK-3a-b_pS21_S9, and Heregulin. Each is linked with EVPLL in more than 1 cancer types. Because this analysis shows association rather than direction, both EVPLL-to-partner and partner-to-EVPLL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVPLL→partner) and Y-score (partner→EVPLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	+0.522	+3.321	.013	.010	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.615	+3.331	.005	.005	3	1
UCEC	Heregulin →	-0.233	-3.169	<.001	.019	3	1
UCEC	N-Ras →	-0.223	-3.308	<.001	.010	3	1
UCEC	P-Cadherin →	-0.249	-3.308	<.001	.010	3	1
UCEC	PRAS40_pT246 →	+0.282	+2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

EVPLL survival (RNA) · tumor vs normal (RNA) · all EVPLL data types