Across TCGA pan-cancer cohorts, EVL mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EVL data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EVL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EVL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where EVL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.703	0.857	.018	7	view →
CCRCC	OS	Median	II,III,IV	0.832	0.628	.030	2	view →
LUAD	DFS	Quartile	All	0.789	0.533	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: EVL tumor-vs-normal RNA expression · all EVL data types