EVI5

Across TCGA patient cohorts, EVI5 mutation is significantly associated with the RNA expression of many other genes, with 6,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVI5-associated genes across cancer lineages are PIGU, LINC00534, and RPS6P20. Each is linked with EVI5 in more than 3 cancer types. Because this analysis shows association rather than direction, both EVI5-to-partner and partner-to-EVI5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGU grouped by EVI5-low versus EVI5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVI5→partner) and Y-score (partner→EVI5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PIGU →	+0.533	+3.214	.001	.009	3	3
LUAD	LINC00534 →	+0.672	+3.944	<.001	.002	3	3
LUSC	RPS6P20 →	+0.074	+2.952	.003	.001	3	3
UCEC	NOC2L →	+0.444	+2.986	<.001	<.001	3	3
UCEC	LIN54 →	+0.641	+4.055	<.001	<.001	3	3
UCEC	C4orf46 →	+0.744	+2.975	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,445 associations by consensus.

PIGU by EVI5 expression — LUSC

Explore this box plot interactively →