EVI5

Across TCGA patient cohorts, EVI5 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVI5-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with EVI5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EVI5-to-partner and partner-to-EVI5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EVI5-low versus EVI5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVI5→partner) and Y-score (partner→EVI5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.462	+1.867	.014	.004	3	3
UCEC	EGFR_pY1068 →	-0.272	-2.058	<.001	<.001	3	2
UCEC	INPP4B →	-0.269	-2.415	.009	.002	3	2
UCEC	Akt_pT308 →	+0.632	+2.415	.001	.002	3	2
UCEC	PKC-delta_pS664 →	-0.090	-2.222	.019	.009	3	2
UCEC	Rab25 →	-0.222	-1.289	.036	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by EVI5 expression — UCEC

Explore this box plot interactively →