EVC2

Across TCGA patient cohorts, EVC2 mutation is significantly associated with the RNA expression of many other genes, with 6,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVC2-associated genes across cancer lineages are FCER1A, CRK, and GLOD4. Each is linked with EVC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both EVC2-to-partner and partner-to-EVC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by EVC2-low versus EVC2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC2→partner) and Y-score (partner→EVC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FCER1A →	-0.968	-3.683	.001	.001	3	5
LUAD	CRK →	+0.353	+2.629	.002	.005	3	4
UCEC	GLOD4 →	+0.386	+1.642	<.001	<.001	3	4
UCEC	TMEM126A →	+0.312	+1.632	<.001	<.001	3	4
UCEC	RRM2 →	+0.923	+2.280	<.001	<.001	3	4
COAD	ATPAF2 →	+0.297	+2.231	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,136 associations by consensus.

FCER1A by EVC2 expression — STAD

Explore this box plot interactively →