EVC2

Across TCGA patient cohorts, EVC2 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVC2-associated genes across cancer lineages are Src_pY527, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with EVC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both EVC2-to-partner and partner-to-EVC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by EVC2-low versus EVC2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC2→partner) and Y-score (partner→EVC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Src_pY527 →	-0.550	-3.584	.001	.002	3	5
COAD	Caspase-7-cleavedD198 →	+0.896	+2.087	<.001	.004	3	4
COAD	c-Met_pY1235 →	+0.133	+2.923	<.001	<.001	3	4
UCEC	C-Raf →	+0.203	+1.938	<.001	.001	3	4
UCEC	FASN →	+0.317	+2.087	.009	.005	3	3
STAD	FoxM1 →	+0.288	+1.905	.001	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Src_pY527 by EVC2 expression — STAD

Explore this box plot interactively →