EVC2

Across TCGA cell cohorts, EVC2 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EVC2-associated genes across cancer lineages are RETREG1, HTR4, and UNCX. Each is linked with EVC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EVC2-to-partner and partner-to-EVC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETREG1 grouped by EVC2-low versus EVC2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC2→partner) and Y-score (partner→EVC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RETREG1 →	+1.866	+3.358	<.001	.003	3	3
OESOPHAGUS	HTR4 →	+0.048	+3.977	<.001	.006	3	2
OESOPHAGUS	UNCX →	+0.413	+3.584	<.001	.008	3	2
OESOPHAGUS	KRTAP3-3 →	+0.090	+4.432	<.001	<.001	3	2
LARGE_INTESTINE	ANKRD54 →	+0.559	+3.237	<.001	.003	3	2
LARGE_INTESTINE	MRPL34 →	+0.440	+2.502	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

RETREG1 by EVC2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →