EVC

Across TCGA patient cohorts, EVC mutation is significantly associated with the RNA expression of many other genes, with 4,882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVC-associated genes across cancer lineages are GSKIP, CD207, and TNFRSF10A. Each is linked with EVC in more than 3 cancer types. Because this analysis shows association rather than direction, both EVC-to-partner and partner-to-EVC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSKIP grouped by EVC-low versus EVC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC→partner) and Y-score (partner→EVC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GSKIP →	+0.838	+2.700	<.001	.006	3	4
UCEC	CD207 →	-0.765	-3.989	<.001	<.001	3	4
UCEC	TNFRSF10A →	+0.546	+1.700	.001	.002	3	4
STAD	PCSK1N →	-2.422	-3.459	<.001	.004	3	3
COAD	C1QBP →	+0.541	+2.013	.001	.005	3	3
STAD	POLR3G →	+0.604	+2.717	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,882 associations by consensus.

GSKIP by EVC expression — STAD

Explore this box plot interactively →