EVC

Across TCGA cell cohorts, EVC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,714 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EVC-associated GO terms across cancer lineages are PML body organization, Negative regulation of Rho protein signal transduction, and Actin filament depolymerization. Each is linked with EVC in more than 12 cancer types. Because this analysis shows association rather than direction, both EVC-to-partner and partner-to-EVC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by EVC-low versus EVC-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC→partner) and Y-score (partner→EVC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PML body organization →	+0.238	+1.817	.001	.006	2	13
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.170	+1.563	<.001	<.001	3	12
SKIN	Actin filament depolymerization →	+0.193	+1.827	<.001	<.001	3	12
SKIN	Protein depolymerization →	+0.133	+1.368	<.001	.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of focal adhesion assembly →	+0.173	+1.956	.002	<.001	3	11
LIVER	Protein localization to endosome →	+0.134	+1.446	.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

PML body organization by EVC expression — LIVER

Explore this box plot interactively →