EVC

Across TCGA cell cohorts, EVC mutation is significantly associated with the mutation status of many other genes, with 3,205 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EVC-associated genes across cancer lineages are FAM47A, SALL3, and ZNF516. Each is linked with EVC in more than 3 cancer types. Because this analysis shows association rather than direction, both EVC-to-partner and partner-to-EVC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47A grouped by EVC-low versus EVC-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC→partner) and Y-score (partner→EVC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM47A →	+3.877	+5.139	.001	.001	1	4
BREAST	SALL3 →	+3.222	+3.222	.009	.009	1	4
STOMACH	ZNF516 →	+3.357	+4.285	.005	.005	1	4
STOMACH	UBR5 →	+2.942	+4.025	.009	.009	1	4
STOMACH	SETX →	+3.942	+4.584	.002	.002	1	4
BLOOD_Leukemia	SNAPC4 →	+2.675	+3.080	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,205 associations by consensus.

FAM47A by EVC expression — CNS

Explore this box plot interactively →