EVA1C

Across TCGA patient cohorts, EVA1C mutation is significantly associated with the RNA expression of many other genes, with 2,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVA1C-associated genes across cancer lineages are SEPTIN14P5, ZC2HC1B, and BTBD10. Each is linked with EVA1C in more than 2 cancer types. Because this analysis shows association rather than direction, both EVA1C-to-partner and partner-to-EVA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P5 grouped by EVA1C-low versus EVA1C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVA1C→partner) and Y-score (partner→EVA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEPTIN14P5 →	+0.051	+6.219	<.001	<.001	3	3
SKCM	ZC2HC1B →	+0.045	+5.075	<.001	.001	3	2
UCEC	BTBD10 →	+0.540	+3.839	<.001	<.001	3	1
UCEC	LIN7C →	+0.465	+2.178	.006	.001	3	1
UCEC	PGAP2 →	+0.394	+2.403	.001	<.001	3	1
UCEC	PTPRJ →	+0.605	+2.010	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,732 associations by consensus.

SEPTIN14P5 by EVA1C expression — SKCM

Explore this box plot interactively →