EVA1C

Across TCGA patient cohorts, EVA1C mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVA1C-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with EVA1C in more than 1 cancer types. Because this analysis shows association rather than direction, both EVA1C-to-partner and partner-to-EVA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EVA1C-low versus EVA1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVA1C→partner) and Y-score (partner→EVA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-2.247	.006	.001	3	1
UCEC	eIF4E →	+0.251	+4.000	.001	<.001	3	1
UCEC	eIF4G →	+0.244	+2.999	.032	.035	3	1
UCEC	A-Raf_pS299 →	-0.107	-2.000	.014	.030	3	1
UCEC	ERK2 →	+0.183	+2.459	.009	.018	3	1
UCEC	JNK2 →	+0.269	+2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by EVA1C expression — UCEC

Explore this box plot interactively →