EVA1A

Across TCGA patient cohorts, EVA1A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVA1A-associated genes across cancer lineages are ERK2, GAPDH, and Ku80. Each is linked with EVA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both EVA1A-to-partner and partner-to-EVA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by EVA1A-low versus EVA1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVA1A→partner) and Y-score (partner→EVA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.222	+3.321	.013	.010	3	1
UCEC	GAPDH →	+0.570	+2.321	.022	.034	3	1
UCEC	Ku80 →	+0.223	+3.009	.042	.019	3	1
UCEC	mTOR_pS2448 →	-0.170	-3.302	.014	.010	3	1
UCEC	p90 RSK →	-0.181	-2.571	.043	.011	3	1
UCEC	PCNA →	+0.353	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by EVA1A expression — UCEC

Explore this box plot interactively →