ETV6

Across TCGA pan-cancer cohorts, ETV6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ETV6 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ETV6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ETV6 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where ETV6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.826	1.000	.029	24	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	21	view →
CCRCC	OS	Quartile	All	0.443	0.940	.011	10	view →
LSCC	DFS	Median	II,III,IV	0.539	0.810	.006	9	view →
LUAD	DFS	Median	II,III,IV	0.651	0.283	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ETV6–COAD (DFS)

Open the COAD breakdown →