ETV6

Across TCGA patient cohorts, ETV6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV6-associated genes across cancer lineages are HSP70, PDK1_pS241, and eIF4E. Each is linked with ETV6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV6-to-partner and partner-to-ETV6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by ETV6-low versus ETV6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV6→partner) and Y-score (partner→ETV6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSP70 →	+0.863	+3.012	.003	.018	3	2
COAD	PDK1_pS241 →	-0.229	-2.991	.008	.036	3	2
UCEC	eIF4E →	+0.187	+2.321	.012	.005	3	2
UCEC	Rad50 →	-0.208	-3.156	.015	.018	3	2
UCEC	VHL →	-0.789	-1.700	<.001	.040	3	2
UCEC	ATM →	-0.413	-1.662	.009	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HSP70 by ETV6 expression — COAD

Explore this box plot interactively →