ETV6

Across TCGA cell cohorts, ETV6 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETV6-associated genes across cancer lineages are MAPK8, HOXB1, and ARHGAP9. Each is linked with ETV6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV6-to-partner and partner-to-ETV6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK8 grouped by ETV6-low versus ETV6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV6→partner) and Y-score (partner→ETV6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAPK8 →	+0.756	+3.385	.002	.004	3	1
LARGE_INTESTINE	HOXB1 →	+0.025	+3.013	<.001	<.001	3	1
LARGE_INTESTINE	ARHGAP9 →	+0.468	+3.299	<.001	.004	3	1
LARGE_INTESTINE	LRRFIP1 →	+0.656	+3.212	.002	.006	3	1
LARGE_INTESTINE	NPHP4 →	+0.658	+3.212	.007	.006	3	1
LARGE_INTESTINE	LARS1 →	+0.650	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

MAPK8 by ETV6 expression — LARGE_INTESTINE

Explore this box plot interactively →