ETV4

Across TCGA patient cohorts, ETV4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV4-associated genes across cancer lineages are PKC-delta_pS664, mTOR, and 14-3-3_zeta. Each is linked with ETV4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETV4-to-partner and partner-to-ETV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by ETV4-low versus ETV4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV4→partner) and Y-score (partner→ETV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.104	-3.169	.035	.018	3	3
BLCA	mTOR →	-0.243	-2.982	.023	.036	3	2
BLCA	14-3-3_zeta →	+0.286	+3.000	.023	.036	3	2
UCEC	Notch1 →	+0.230	+2.321	<.001	.006	3	2
UCEC	Di-Ras3 →	-0.156	-2.321	.011	.006	3	2
BLCA	Tuberin →	-0.461	-3.000	.012	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PKC-delta_pS664 by ETV4 expression — UCEC

Explore this box plot interactively →