ETV4

Across TCGA cell cohorts, ETV4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,199 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ETV4-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and T-helper 17 type immune response. Each is linked with ETV4 in more than 12 cancer types. Because this analysis shows association rather than direction, both ETV4-to-partner and partner-to-ETV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lens fiber cell differentiation grouped by ETV4-low versus ETV4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV4→partner) and Y-score (partner→ETV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of lens fiber cell differentiation →	+1.163	+1.984	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of lens fiber cell differentiation →	+1.166	+1.981	<.001	<.001	3	10
LUNG_NSCLC_LUSC	T-helper 17 type immune response →	-0.203	-1.827	<.001	.008	3	8
BONE	Negative regulation of ERBB signaling pathway →	+0.142	+2.292	<.001	<.001	3	8
OVARY	D-ribose metabolic process →	+0.165	+1.339	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Positive regulation of epidermal cell differentiation →	+0.212	+2.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,199 associations by consensus.

Negative regulation of lens fiber cell differentiation by ETV4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →