ETV4

Across TCGA cell cohorts, ETV4 mutation is significantly associated with the mutation status of many other genes, with 3,143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETV4-associated genes across cancer lineages are MORC1, MGAT3, and PHF20L1. Each is linked with ETV4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETV4-to-partner and partner-to-ETV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORC1 grouped by ETV4-low versus ETV4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV4→partner) and Y-score (partner→ETV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MORC1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	MGAT3 →	+4.700	+5.050	<.001	<.001	1	3
BLOOD_Lymphoma	PHF20L1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	EPRS1 →	+3.548	+3.845	.003	.003	1	3
BLOOD_Lymphoma	LRRC8A →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	KIF21A →	+2.963	+3.960	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,143 associations by consensus.

MORC1 by ETV4 expression — BLOOD_Lymphoma

Explore this box plot interactively →