ETV1

Across TCGA patient cohorts, ETV1 mutation is significantly associated with the RNA expression of many other genes, with 5,806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV1-associated genes across cancer lineages are PHF5A, COX15, and RPL23AP82. Each is linked with ETV1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ETV1-to-partner and partner-to-ETV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by ETV1-low versus ETV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV1→partner) and Y-score (partner→ETV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.517	+2.169	<.001	<.001	3	4
SKCM	COX15 →	+0.472	+2.642	.007	.005	3	3
SKCM	RPL23AP82 →	+0.711	+2.591	<.001	.006	3	3
UCEC	NDUFA6 →	+0.471	+3.544	<.001	<.001	3	3
COAD	POLH-AS1 →	+0.598	+3.210	<.001	.009	3	3
COAD	CHUK →	+0.489	+3.472	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,806 associations by consensus.

PHF5A by ETV1 expression — UCEC

Explore this box plot interactively →