ETS2

Across TCGA patient cohorts, ETS2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETS2-associated genes across cancer lineages are ACC1, Heregulin, and eEF2. Each is linked with ETS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETS2-to-partner and partner-to-ETS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ETS2-low versus ETS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETS2→partner) and Y-score (partner→ETS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.336	+3.013	.025	.018	3	2
SKCM	Heregulin →	+0.185	+2.820	.038	.035	3	2
UCEC	eEF2 →	+0.371	+2.321	.012	.033	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.459	.005	.019	3	1
UCEC	ERK2 →	+0.203	+1.807	.010	.027	3	1
UCEC	GATA6 →	-0.155	-1.800	.015	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ACC1 by ETS2 expression — UCEC

Explore this box plot interactively →