ETNK1

Across TCGA pan-cancer cohorts, ETNK1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ETNK1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ETNK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ETNK1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

BLCA, HNSC, and KIRC are the cancer types where ETNK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETNK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.142	<.001	11	view →
HNSC	All	III,IV	+0.662	<.001	8	view →
KIRC	Male	III,IV	−0.572	<.001	8	view →
THCA	Male	All	−0.497	<.001	6	view →
BRCA	All	II,III,IV	+0.433	<.001	6	view →
CHOL	Male	All	+1.710	<.001	5	view →
COAD	All	All	−0.741	.001	5	view →
STAD	All	All	+0.889	.001	4	view →
LIHC	All	All	+0.404	<.001	3	view →
PAAD	Male	All	+0.980	.008	2	view →
LUAD	Female	III,IV	−0.613	.015	2	view →
READ	All	All	+0.683	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ETNK1–BLCA

Open the BLCA breakdown →