ETNK1

Across TCGA pan-cancer cohorts, ETNK1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ETNK1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ETNK1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ETNK1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where ETNK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETNK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.314	<.001	8	view →
LUAD	All	II,III,IV	+0.264	<.001	8	view →
HNSC	All	All	+0.226	<.001	8	view →
CCRCC	Male	All	−0.138	<.001	6	view →
LSCC	All	All	+0.139	.001	4	view →
PDAC	Female	II,III,IV	+0.515	.012	3	view →
OV	All	All	+0.372	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ETNK1–COAD

Open the COAD breakdown →