ETHE1

Across TCGA patient cohorts, ETHE1 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETHE1-associated genes across cancer lineages are OR7E53P, RPS3AP9, and MRPL51P2. Each is linked with ETHE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETHE1-to-partner and partner-to-ETHE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E53P grouped by ETHE1-low versus ETHE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETHE1→partner) and Y-score (partner→ETHE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR7E53P →	+0.051	+3.174	.008	.002	3	2
CESC	RPS3AP9 →	+0.049	+4.503	.003	.005	3	2
BLCA	MRPL51P2 →	+0.114	+7.640	<.001	.009	3	2
SKCM	SNORD113-1 →	+0.403	+4.614	<.001	.006	3	2
COAD	LINC01853 →	+0.387	+7.741	<.001	.009	3	2
UCEC	CCR8 →	+0.650	+3.223	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

OR7E53P by ETHE1 expression — UCEC

Explore this box plot interactively →