ETHE1

Across TCGA patient cohorts, ETHE1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETHE1-associated genes across cancer lineages are Ku80, VHL, and GAPDH. Each is linked with ETHE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETHE1-to-partner and partner-to-ETHE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ETHE1-low versus ETHE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETHE1→partner) and Y-score (partner→ETHE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.353	+3.013	.009	.019	3	1
UCEC	VHL →	-1.111	-3.000	.004	.037	3	1
UCEC	GAPDH →	+0.688	+3.000	.026	.037	1	1
UCEC	p21 →	+0.279	+3.000	.012	.037	1	1
UCEC	CD49b →	-0.334	-2.986	.042	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by ETHE1 expression — UCEC

Explore this box plot interactively →