ETHE1

Across TCGA cell cohorts, ETHE1 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ETHE1-associated genes across cancer lineages are GFRA4, MAGEB4, and STRA8. Each is linked with ETHE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETHE1-to-partner and partner-to-ETHE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by ETHE1-low versus ETHE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETHE1→partner) and Y-score (partner→ETHE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.030	+4.930	<.001	.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPX5 →	+0.318	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

GFRA4 by ETHE1 expression — LARGE_INTESTINE

Explore this box plot interactively →