ETHE1

Across TCGA cell cohorts, ETHE1 mutation is significantly associated with the mutation status of many other genes, with 1,936 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ETHE1-associated genes across cancer lineages are EXOSC10, RUSC2, and KPRP. Each is linked with ETHE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETHE1-to-partner and partner-to-ETHE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC10 grouped by ETHE1-low versus ETHE1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETHE1→partner) and Y-score (partner→ETHE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EXOSC10 →	+4.297	+4.857	.009	.009	1	3
BREAST	RUSC2 →	+4.297	+4.857	.009	.009	1	3
BREAST	KPRP →	+5.297	+5.297	.004	.004	1	3
LARGE_INTESTINE	LPCAT3 →	+5.087	+4.523	.006	.006	1	3
BLOOD_Leukemia	FOXP1 →	+3.063	+3.498	.006	.006	1	3
LARGE_INTESTINE	TUT1 →	+4.087	+5.044	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

EXOSC10 by ETHE1 expression — BREAST

Explore this box plot interactively →