ETFB

Across TCGA patient cohorts, ETFB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETFB-associated genes across cancer lineages are INPP4B, JNK2, and MSH2. Each is linked with ETFB in more than 1 cancer types. Because this analysis shows association rather than direction, both ETFB-to-partner and partner-to-ETFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ETFB-low versus ETFB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETFB→partner) and Y-score (partner→ETFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.283	-2.459	.039	.019	3	1
UCEC	JNK2 →	+0.291	+3.196	<.001	.009	3	1
UCEC	MSH2 →	-0.228	-2.312	.019	.034	3	1
UCEC	Notch1 →	+0.151	+1.884	.011	.030	3	1
UCEC	p62 Lck ligand →	+0.291	+2.179	.035	.034	3	1
UCEC	Rad50 →	-0.203	-2.222	.048	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

INPP4B by ETFB expression — UCEC

Explore this box plot interactively →