ETFA

Across TCGA patient cohorts, ETFA mutation is significantly associated with the RNA expression of many other genes, with 1,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETFA-associated genes across cancer lineages are CICP21, OR2AF1P, and LINC01744. Each is linked with ETFA in more than 1 cancer types. Because this analysis shows association rather than direction, both ETFA-to-partner and partner-to-ETFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CICP21 grouped by ETFA-low versus ETFA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETFA→partner) and Y-score (partner→ETFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CICP21 →	+0.036	+4.086	.009	.002	3	1
SKCM	OR2AF1P →	+0.178	+4.362	<.001	.001	3	1
SKCM	LINC01744 →	+0.046	+3.623	<.001	.006	3	1
SKCM	TEX36-AS1 →	+0.033	+4.624	<.001	.005	3	1
SKCM	RNU6-956P →	+1.104	+4.469	<.001	.006	3	1
UCEC	CCL5 →	+1.279	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,562 associations by consensus.

CICP21 by ETFA expression — SKCM

Explore this box plot interactively →