ESYT3

Across TCGA patient cohorts, ESYT3 mutation is significantly associated with the RNA expression of many other genes, with 2,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESYT3-associated genes across cancer lineages are KRTAP3-4P, RNA5SP412, and AHSA1. Each is linked with ESYT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESYT3-to-partner and partner-to-ESYT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP3-4P grouped by ESYT3-low versus ESYT3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT3→partner) and Y-score (partner→ESYT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	KRTAP3-4P →	+0.113	+4.289	<.001	.007	3	3
LUAD	RNA5SP412 →	+0.168	+7.930	<.001	.008	3	3
UCEC	AHSA1 →	+0.412	+1.868	<.001	<.001	3	3
UCEC	GRPEL1 →	+0.467	+2.115	<.001	<.001	3	3
UCEC	YARS1 →	+0.582	+1.890	<.001	<.001	3	3
UCEC	SURF4 →	+0.546	+1.857	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,399 associations by consensus.

KRTAP3-4P by ESYT3 expression — BLCA

Explore this box plot interactively →