ESYT3

Across TCGA cell cohorts, ESYT3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ESYT3-associated genes across cancer lineages are RGS21, G6PC2, and KRT82. Each is linked with ESYT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESYT3-to-partner and partner-to-ESYT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGS21 grouped by ESYT3-low versus ESYT3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT3→partner) and Y-score (partner→ESYT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RGS21 →	+0.005	+4.614	<.001	.004	3	2
CNS	G6PC2 →	+0.017	+3.887	<.001	.001	3	2
LUNG_SCLC	KRT82 →	+0.021	+4.523	<.001	.003	3	2
PANCREAS	GZMK →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	GJA10 →	+0.272	+4.786	<.001	.001	3	1
PANCREAS	OR10H5 →	+0.018	+4.237	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

RGS21 by ESYT3 expression — PANCREAS

Explore this box plot interactively →