ESYT2

Across TCGA patient cohorts, ESYT2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESYT2-associated genes across cancer lineages are A-Raf_pS299, N-Ras, and Rad50. Each is linked with ESYT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESYT2-to-partner and partner-to-ESYT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ESYT2-low versus ESYT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT2→partner) and Y-score (partner→ESYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.116	-1.584	.002	.034	3	2
COAD	N-Ras →	-0.178	-3.000	.012	.035	3	2
UCEC	Rad50 →	-0.171	-1.459	.029	.012	3	2
UCEC	STAT3_pY705 →	-0.313	-1.362	<.001	.031	3	2
UCEC	TAZ →	-0.107	-1.575	.019	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.662	+1.827	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by ESYT2 expression — UCEC

Explore this box plot interactively →