ESYT2

Across TCGA cell cohorts, ESYT2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESYT2-associated genes across cancer lineages are OR8D2, ZSCAN20, and SCGB2A1. Each is linked with ESYT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESYT2-to-partner and partner-to-ESYT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D2 grouped by ESYT2-low versus ESYT2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT2→partner) and Y-score (partner→ESYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR8D2 →	+0.029	+3.643	.004	.007	3	1
LARGE_INTESTINE	ZSCAN20 →	+0.537	+3.125	.001	.008	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.674	+3.614	<.001	.001	3	1
LARGE_INTESTINE	PLVAP →	+0.182	+3.539	.003	.004	3	1
LARGE_INTESTINE	MS4A7 →	+0.029	+3.657	.006	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.064	+2.823	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

OR8D2 by ESYT2 expression — CNS

Explore this box plot interactively →