ESYT1

Across TCGA patient cohorts, ESYT1 mutation is significantly associated with the RNA expression of many other genes, with 4,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESYT1-associated genes across cancer lineages are PSMC3IP, SLC25A33, and ZNF79. Each is linked with ESYT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESYT1-to-partner and partner-to-ESYT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by ESYT1-low versus ESYT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT1→partner) and Y-score (partner→ESYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.623	+2.595	<.001	<.001	3	3
UCEC	SLC25A33 →	+0.525	+2.695	<.001	<.001	3	3
UCEC	ZNF79 →	+0.509	+1.999	<.001	<.001	3	3
UCEC	C4orf46 →	+0.458	+1.551	.002	.002	3	3
UCEC	CENPU →	+0.671	+1.787	<.001	<.001	3	3
UCEC	NAE1 →	+0.533	+1.999	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,827 associations by consensus.

PSMC3IP by ESYT1 expression — UCEC

Explore this box plot interactively →