ESYT1

Across TCGA cell cohorts, ESYT1 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESYT1-associated genes across cancer lineages are C2orf73, SLC32A1, and DNAI1. Each is linked with ESYT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESYT1-to-partner and partner-to-ESYT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf73 grouped by ESYT1-low versus ESYT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESYT1→partner) and Y-score (partner→ESYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C2orf73 →	+0.038	+3.187	.001	.001	3	2
BLOOD_Leukemia	SLC32A1 →	+0.771	+2.638	<.001	.009	3	1
BLOOD_Leukemia	DNAI1 →	+0.164	+3.257	<.001	.009	3	1
BLOOD_Leukemia	MMP27 →	+0.011	+4.232	<.001	<.001	3	1
BLOOD_Leukemia	FAM71A →	+0.034	+3.147	.003	.002	3	1
BLOOD_Leukemia	ADORA1 →	+0.583	+3.312	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

C2orf73 by ESYT1 expression — BLOOD_Leukemia

Explore this box plot interactively →