ESX1

Across TCGA patient cohorts, ESX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,426 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible ESX1-associated GO terms across cancer lineages are Protein localization to chromosome, Negative regulation of mitotic cell cycle phase transition, and Positive regulation of cell cycle G2/M phase transition. Each is linked with ESX1 in more than 10 cancer types. Because this analysis shows association rather than direction, both ESX1-to-partner and partner-to-ESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to chromosome grouped by ESX1-low versus ESX1-high in UCEC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESX1→partner) and Y-score (partner→ESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Protein localization to chromosome →	+0.024	+0.067	<.001	<.001	3	10
THYM	Negative regulation of mitotic cell cycle phase transition →	+0.032	+0.041	<.001	.001	2	11
STAD	Positive regulation of cell cycle G2/M phase transition →	+0.075	+0.271	<.001	<.001	3	10
STAD	Regulation of cyclin-dependent protein kinase activity →	+0.066	+0.216	<.001	<.001	2	11
THYM	DNA conformation change →	+0.039	+0.070	<.001	<.001	3	10
STAD	Regulation of DNA-templated DNA replication initiation →	+0.078	+0.169	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,426 associations by consensus.

Protein localization to chromosome by ESX1 expression — UCEC

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