ESX1

Across TCGA cell cohorts, ESX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 77 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible ESX1-associated GO terms across cancer lineages are Response to epidermal growth factor, Response to glucose, and Negative regulation of tumor necrosis factor superfamily cytokine production. Each is linked with ESX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ESX1-to-partner and partner-to-ESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to epidermal growth factor grouped by ESX1-low versus ESX1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESX1→partner) and Y-score (partner→ESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Response to epidermal growth factor →	+0.054	+0.283	.005	.002	3	4
PANCREAS	Response to glucose →	+0.043	+0.273	.001	.004	3	3
PANCREAS	Negative regulation of tumor necrosis factor superfamily cytokine production →	+0.098	+0.431	<.001	.009	2	4
PANCREAS	Negative regulation of interleukin-1 production →	+0.112	+0.264	<.001	.005	3	3
PANCREAS	Cellular response to epidermal growth factor stimulus →	+0.065	+0.291	.001	.005	3	3
LUNG_NSCLC_LUAD	Postsynaptic intermediate filament cytoskeleton organization →	+1.177	+0.133	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Response to epidermal growth factor by ESX1 expression — PANCREAS

Explore this box plot interactively →