ESS2

Across TCGA patient cohorts, ESS2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESS2-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and Notch1. Each is linked with ESS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESS2-to-partner and partner-to-ESS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ESS2-low versus ESS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESS2→partner) and Y-score (partner→ESS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.138	-2.321	.007	.033	3	2
UCEC	mTOR_pS2448 →	-0.163	-3.565	.008	.002	3	2
UCEC	Notch1 →	+0.164	+2.321	.004	.006	3	2
COAD	PCNA →	+0.363	+2.815	.007	.036	3	2
UCEC	EGFR_pY1068 →	-0.239	-1.807	.021	.027	3	1
UCEC	eIF4E →	+0.193	+3.335	.026	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FOXO3a_pS318_S321 by ESS2 expression — UCEC

Explore this box plot interactively →